Update on Abilify Maintena Use!

July 22, 2013 at 3:52 pm | Posted in 2013, Abilify, Abilify Maintena, Bipolar, crazy, drugs, Haldol, Haldol DEC, Haldol Decanoate, insanity, Kristin Bell, long-acting injectables, Medicine, Mental Health, Mental Illness, negative symptoms, Paranoid Schizophrenia, Prescription Meds, Psych Meds, Psychiatrist, Psychiatry, Psychiatry Denial, Psycho, Psychoactive Substances, Psychology, Psychosis, schizoaffective disorder, Schizophrenia, Science, symptoms, treatment, treatment-resistant | Leave a comment
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Schizophrenia and Negative Symptoms: Q&A with Dr. Potkin

May 20, 2013 at 7:48 pm | Posted in 2013, Abilify, affective flattening, alogia, Anti-anxiety meds, Anti-depressants, Anti-psychotics, asociality, avolition, Biology, Bipolar, Brain, Depakote, Depression, dopamine hypothesis, Dr. Steven G. Potkin, drugs, Education, Genentech, Geodon, Haldol, Haldol DEC, Haldol Decanoate, Health, insanity, Irvine (UCI), Kristin Bell, Lithium, Mania, Manic, Medicine, Mental Health, Mental Illness, Mood Stabilizers, N-methyl-D-aspartate, NAMI, negative symptoms, neuron, neuroscience, neurotransmitters, NMDA, NMDA receptor hypofunction hypothesis, Paranoid Schizophrenia, Paxil, Prescription Meds, Psych Meds, Psychiatrist, Psychiatry, Psychiatry Denial, Psycho, Psychoactive Substances, psychoanalysis, Psychology, Psychosis, Risperdal, schizoaffective disorder, Schizophrenia, Science, Seroquel, stigma, Support System, Surviving, symptoms, synapse, sz, Therapist, Trazadone, treatment, treatment-resistant, Trilifon, Wellbutrin, Zoloft, Zyprexa | Leave a comment

negsymp I have some great news! I was able to ask Dr. Steven G. Potkin, Professor of Psychiatry in the Department of Psychiatry and Human Behavior at the University of California, Irvine (UCI) Medical Center, some questions regarding the negative symptoms of schizophrenia. He is also the Robert R. Sprague Endowed Chair in Brain Imaging. It was a brief, by email interview, but I’m happy to share what I’ve learned with you all! The following is the Q&A:

Kristin: What are negative symptoms?
Dr. Potkin: “Negative” does not refer to a person’s attitude, but instead to a lack of characteristics that should be present. Symptoms include reduced amount and content of speech, even when encouraged to interact (alogia), lack of emotional and facial expression (affective flattening), diminished ability to begin and sustain activities (avolition), decreased ability to find pleasure in everyday life (anhedonia) and social withdrawal (asociality). [1] [2]

Negative symptoms can appear a few years before other symptoms appear in young adulthood in the so-called “prodromal” stage of the illness.[3] Unfortunately these symptoms often go undetected because they manifest themselves as issues common among teenagers: social withdrawal, problems with school work, irritability, depression and sleeping problems.[4]

Kristin: Do all people with schizophrenia have negative symptoms?
Dr. Potkin: No, but at any point in time, negative symptoms can affect approximately 50 percent or more of people with schizophrenia.[5] [6]

Kristin: How do negative symptoms affect a person with schizophrenia? How do they affect their family and friends?
Dr. Potkin: Research suggests that for people living with schizophrenia, negative symptoms are key factors in poor quality of life as well as problems with personal hygiene, school and work performance, maintaining relationships, interacting within the community, and participating in social activities. [7] [8] [9] [10]

For caregivers of people with schizophrenia, negative symptoms may cause more burden than do other types of symptoms as they see their loved ones life isolated and lacking in meaning or joy. [11]

Kristin: How are negative symptoms currently treated?
Dr. Potkin: Current treatments for schizophrenia focus on reducing characteristic symptoms and can include both medication and psychosocial interventions.[12] No effective medication treatment has yet been approved for specific treatment of negative symptoms. Despite progress in the medication side of treatment, there are still unmet needs in terms of symptom control. A large study found that despite treatment, approximately 57 percent of people receiving treatment for a schizophrenia spectrum disorder still had at least one negative symptom.[10]

Kristin: What is the research that Genentech is doing regarding negative symptoms?
Dr. Potkin: Researchers at Genentech are pursuing new treatment strategies for schizophrenia, including increasing N-methyl-D-aspartate (NMDA) receptor activity in the brain in order to target the mechanism that may be a common link between the positive, negative and cognitive symptoms of the disorder.[7] [9] [11] [12]

Specifically, through a clinical trial program, Genentech is looking at an investigational medication for people with schizophrenia, including people who experience mostly negative symptoms of schizophrenia, despite taking medication. For more information, please visit www.SearchLyteschizophrenia.com

Kristin: How can family and friends of someone with schizophrenia help someone with negative symptoms?
Dr. Potkin: Caregivers can talk to doctors about interventions including medication, psychosocial rehabilitation (work, school, relationships), medical care and wellness, and therapy (e.g. cognitive behavioral therapy and peer support groups), as well as ongoing clinical trials.[13] They can work with physicians to find the medications and non-medicine therapies that are right for their loved one. Different medicines may have different side effects. Caregivers can also consider programs from the National Alliance on Mental Illness (NAMI) including:

• NAMI Hearts and Minds

– Online, interactive wellness initiative

www.nami.org/heartsandminds

• NAMI Peer-to-Peer

– Free, 9-week educational course on recovery

www.nami.org/peertopeer

• NAMI Connection

– Recovery support group for adults

www.nami.org/connection

Kristin: Do scientists know the biological mechanisms involved in negative symptoms? If so, what are the areas of the brain and/or mechanisms involved in negative symptoms?
Dr. Potkin: In the 1970s, the “dopamine hypothesis” of schizophrenia emerged, suggesting the biological basis of schizophrenia was an excess of signaling by dopamine, a chemical messenger in the brain. This theory, however, could not explain negative or cognitive symptoms.[6] In the late 1980’s a newer theory suggested positive, negative and cognitive symptoms could all be due to reduced function of NMDA receptors in the brain. This theory is now known as the “NMDA receptor hypofunction hypothesis.”[6] [7] [8] [9]

Researchers are pursuing new treatment strategies for schizophrenia, including increasing NMDA receptor function in the brain in order to target the mechanism that may be a common link between the positive, negative and cognitive symptoms of the disorder.[7] [9] [11] [12] It is thought that NMDA receptor activity is an important pathway in psychiatric disorders, especially schizophrenia.

End of article.

*Note: I would like to thank Dr. Potkin for helping me put together this interview. This research is very exciting and I hope that negative symptoms can be tackled in this decade! I know how debilitating they can be!

______________________________

1.     Gard DE, Kring AM, Gard MG, Horan WP, Green MF. Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res. Jul 2007;93(1-3):253-260.

2.     Strauss GP, Gold JM. A new perspective on anhedonia in schizophrenia. Am J Psychiatry. Apr 2012;169(4):364-373.

3.     Stahl SM. Stahl’s Essential Psychopharacology: Neuroscientific Basis and Practical Applications. 3rd ed. New York: Cambridge University Press; 2008.

4.     National Institute of Mental Health. Schizophrenia. 2009; http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml. Accessed July 7, 2012.

5.     Kirkpatrick B, Fenton WS, Carpenter WT, Jr., Marder SR. The NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull. Apr 2006;32(2):214-219.

6.     Bobes J, Arango C, Garcia-Garcia M, Rejas J. Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study. J Clin Psychiatry. Mar 2010;71(3):280-286.

7.     Ho BC, Nopoulos P, Flaum M, Arndt S, Andreasen NC. Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. Am J Psychiatry. Sep 1998;155(9):1196-1201.

8.     Kirkpatrick B, Fenton WS, Carpenter WT, Jr., Marder SR. The NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull. Apr 2006;32(2):214-219.

9.     Kurtz MM. Symptoms versus neurocognitive skills as correlates of everyday functioning in severe mental illness. Expert Rev Neurother. Jan 2006;6(1):47-56.

10.   Milev P, Ho BC, Arndt S, Andreasen NC. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. Am J Psychiatry. Mar 2005;162(3):495-506.

11.   Provencher HL, Mueser KT. Positive and negative symptom behaviors and caregiver burden in the relatives of persons with schizophrenia. Schizophr Res. Jul 25 1997;26(1):71-80.

12.   National Institute of Mental Health. Schizophrenia. 2009; http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml. Accessed July 7, 2012.

13.   National Institute of Mental Health. Schizophrenia. 2009; http://www.nimh.nih.gov/health/publications/schizophrenia/complete-index.shtml. Accessed July 7, 2012.

Earth Science Fabric for Spoonflower Contest

September 10, 2012 at 11:07 pm | Posted in 2012, Art, arts & crafts, earth, earth science, fabric, fabric design, geology, Handmade, Kristin Bell, plate tectonics, quilt, quilting, school, Science, sewing, sewn, spoonflower | Leave a comment

I just got my Earth Science fabric in the mail today that I made for the spoonflower.com Earth Science fabric contest. I like the way it turned out, but I don’t know what to use it for yet. I might make another pillow or try something more exciting. :) Here is a link to the fabric on spoonflower if you are interested: http://www.spoonflower.com/fabric/1407354. You can click the pics to zoom in and enlarge.

Genetic Testing! Yay!

August 24, 2012 at 9:30 pm | Posted in Abilify, Anti-anxiety meds, Anti-depressants, Anti-psychotics, Anxiety, benadryl, Biology, Bipolar, Body, BPD, Buspar, Depakote, Depression, dna, drugs, Effexor, genetic testing, Genetics, Haldol, Haldol DEC, Haldol Decanoate, Kristin Bell, Lithium, Mania, Manic, Manic-Depressive, MAO Inhibitors, Medicine, Mental Health, Mental Illness, metabolic pathways, metabolize, Mood Stabilizers, Navane, neuroscience, Obsessive-Compulsive Disorder, ocd, Paranoid Schizophrenia, Paxil, plavix, Prescription Meds, Prozac, Psych Meds, Psychiatrist, Psychiatry, Psychoactive Substances, Psychology, Psychosis, Risperdal, schizoaffective disorder, Schizophrenia, Science, Seroquel, Technology, testing, Trazadone, Trilifon, warfarin, Wellbutrin, Zoloft, Zyprexa | Leave a comment

http://www.genemedrx.com/

Hey Everybody! I wanted to share with you this cool genetics testing that is available to people. I just got it done, because my nurse practitioner ordered it and Medicare pays for it. (Medicare pays for this testing, because it saves a LOT of money and can save lives!) It is really cool, because it tells you how medications will interact with your specific genetic makeup! It is extremely important if you are taking really any kind of medication. For example, had I known about my results before I took Wellbutrin years ago, it would have saved me from basically having a manic reaction to the medication. It turns out that I metabolize differently than normal on some of the metabolic pathways. This means that I will metabolize the meds on those pathways different than people without this issue. If you have Medicare, I strongly urge you to get this testing done. It could save your life from a bad genetic-medication mistake. I think many other insurance carriers might also pay for it. It also explains why I can take a lower dose of many medications and still get the desired effect from the medication. I would say that anyone who is trying to figure out their psych meds should really get this testing done too. It doesn’t just tell about psych meds though, it tells about stuff involving all other sorts of meds. Seriously, this is pretty awesome! Again, here is the link: http://www.genemedrx.com/

Congratulations NASA!!!

August 5, 2012 at 11:14 pm | Posted in Curiosity, Engineering, landing, Mars, math, NASA, Science, Space | Leave a comment

So excited that Curiosity landed safely and with success on Mars! Here are a couple of pics! When the servers come back up, you should be able to see the raw images as they come in here: http://mars.jpl.nasa.gov/msl/multimedia/raw/

The Visual System: 7th Drawing for Neuro Class

March 4, 2012 at 5:43 am | Posted in Art, drawings, eyes, fovea, Illustrated, Kristin Bell, Mental Health, neuroscience, optic, Psychiatry, Psychology, retina, rods and cones, Science, Seeing, sight, visual system | Leave a comment

I didn’t have time to do a complete job on this one, but I got it done! lol To see a bigger image, just click on the picture.

The Auditory System: 6th Drawing for Neuroscience Class

February 20, 2012 at 12:55 am | Posted in Art, audio, audition, auditory system, basilar membrane, Biology, Brain, cochlea, drawings, ear drum, ears, hearing, Heschl's Gyrus, Kristin Bell, Medicine, Mental Health, Mental Illness, neuroscience, ossicles, Psychiatry, Psychology, Science, sound, tectorial membrane | 2 Comments

This last week we were learning about the auditory system in neuroscience class. These are the drawings I came up with for the assignment we had to do. He said that they didn’t have to be anatomically correct and could be schematic, so the second picture is more of a schematic drawing.

Interesting Article: New Genetic Thinking in Mental Illness

May 18, 2011 at 2:10 am | Posted in Biology, Genetics, Kristin Bell, Mental Health, Mental Illness, Psychiatry, Schizophrenia, Science | Leave a comment

http://www.scientificamerican.com/article.cfm?id=new-genetics-work-challenges-basic-ideas-about-mental-illness

Interesting Video: Reclaiming DaVinci

May 18, 2011 at 1:36 am | Posted in Art, Computers, Computing, Kristin Bell, Mathematics, Science, Vision, Visualization | Leave a comment

Review: Packing for Mars-The Curious Science of Life in the Void

September 2, 2010 at 10:46 pm | Posted in Astronauts, Astronomy, Biology, Books, Cosmonauts, Kristin Bell, Mars, Moon, NASA, Physics, Science, Space Travel | Leave a comment

“Packing for Mars: The Curious Science of Life in the Void” by Mary Roach will probably make a wanna-be astronaut out of you if you aren’t already! Simply put, this book is FANTASTIC! I fell in love with the idea of space travel all over again. Roach’s writing is top notch and very humorous. This book was a joy to read and it makes me want to have a bake sale to help fund space missions or something. People often ask “why go to space when there are so many problems on THIS planet?!?” and I think that Mary Roach has an answer for them. Get this book and read it! I can’t imagine anyone not loving it! (  )

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